Midbrain local circuits shape sound intensity codes

Hierarchical processing of sensory information requires interaction at multiple levels along the peripheral to central pathway.Recent evidence suggests that interaction between driving and modulating components can shape both top down and bottom up processing of sensory information.Here we show that a component inherited from extrinsic sources comb

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Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies lacking effective therapies.KRAS mutations that occur in over 90% of PDAC are major oncogenic drivers of PDAC.The MAPK signaling pathway plays a central role in KRAS-driven oncogenic signaling.However, pharmacological inhibitors of the MAPK pathway are poo

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Information Security Risk Management Web-Based Final Semester Summative Assessment Application Using ISO 27001:2013

Education is often understood as more than just teaching, but as the transfer of knowledge, transformation of values, and development of character with all related aspects.Digitalization of the need for information and communication technology is increasing to facilitate access to information systems.This research was conducted at SMAN 12 Bandung w

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